Review Article
Paving Plant-Food-Derived Bioactives as Effective Therapeutic Agents in Autism Spectrum Disorder
Table 4
Summary of clinical studies.
| Phytocompounds | Subjects | Results | Reference |
| Food supplements including choline, folic acid, and multivitamins | Pregnant patient | Reduced expression of ASD-related genes | [189] | Omega-3 and vitamin D | Case study of ASD patient | Reduced ASD symptom | [190] | Metformin | ASD adult patients | Stabilized BMI -score | [118] | Cannabis and cannabidiol | ASD adult patients | Reduced ASD symptom | [193] | Luteolin and quercetin | Children with ASD | Improvement in gastrointestinal features, eye contact, and attention social interactions | [194] | Luteolin, quercetin, and rutin | Children with ASD | Improvement in adaptive functioning and in overall behavior | [77] | Co-ultra-PEA-LUT | ASD adult patients | Reduced motor stereotypes, anxiety, and worsening in social skills | [186] | PEA | Children with ASD | Improvement of cognitive aspects, expressive language, and sociability Reduced general severity of autism | [195] | Flavonoid component extracted from G. biloba | ASD adult patients | Slight improvements in irritability, hyperactivity, eye contact, and speech | [84] |
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