Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury

Figure 2

Schematic representation of the proposed mechanism of ferroptosis mediating cell death during ischemia-reperfusion and the mechanism of regulatory pathways of ferroptosis. SLC3A2: solute carrier family 3 member 2; SLC7A11: solute carrier family 7 member 11; Keap1: Kelch-like ECH-associated protein 1; NRF2: nuclear factor erythroid 2-related factor; HO-1: heme oxygenase-1; NCOA4: nuclear receptor coactivator 4; HSPB1: heat shock factor-binding protein 1; TFR1: transferrin receptor 1; FIN56: ferroptosis inducing 56; FSP1: ferroptosis suppressor protein 1; CoQ10: coenzyme Q10; RSL3: (1S, 3R)-RSL; GSH: glutathione; GPX4: glutathione peroxidase 4; ROS: reactive oxygen species; SAT1: spermidine/spermine N¹-acetyltransferase 1; ALOX-15: arachidonate lipoxygenase 15; AA: arachidonic acid; ACSL4: acyl-CoA synthetase long-chain family 4; LPCAT3: lysophosphatidylcholine acyltransferase 3; ALOXs: arachidonate lipoxygenases; PE: phosphatidylethanolamine.