Targeting Ferroptosis: Pathological Mechanism and Treatment of Ischemia-Reperfusion Injury

Table 1

Studies reporting the mechanisms and targets of ferroptosis in ischemia-reperfusion injury.

Ferroptosis in I/R injury	Experiment	Number ()	Model/study population	Intervention	Target	Reference
Myocardial I/R injury	In vitro	Not applicable	Mouse embryonic fibroblasts	Not available	Glutaminolysis	[70]
	In vitro	Not applicable	H9c2 cells	C3G	Ferroptosis-related protein, NCOA4, RSL3	[72]
	In vitro	Not applicable	Adult rat cardiomyocytes	Ferrostatin-1	OxPCs	[76]
	In vitro	Not applicable	H9c2 cells	Baicalin	ACSL4	[82]
	In vitro	Not applicable	Human cardiomyocytes	ELAVL1 knockout	Not available	[84]
	In vivo	Not applicable	I/R-treated Sprague–Dawley rats	Not available	Upregulation of USP7	[74]
	In vivo	Not applicable	Murine models of doxorubicin- and I/R-induced cardiomyopathy	Ferrostatin-1 and iron chelator	Not available	[77]
	In vivo	Not applicable	Sprague–Dawley rats	C3G	Ferroptosis-related protein, NCOA4, RSL3	[72]
	In vivo	Not applicable	Myocardial I/R rat model	Baicalin	ACSL4	[82]
	In vivo	Not applicable	Sprague–Dawley rats	USP22	Not available	[83]
	Clinical finding	60	Patients with ST-elevation-myocardial infarct	DFO	Not available	[78]
	Clinical finding	45	Patients undergoing coronary artery bypass grafting	DFO	Not available	[79]
Cerebral I/R injury	In vitro	Not applicable	Primary cortical neurons and hippocampal HT22 cells	Selenium	GPX4	[92]
	In vivo	Not applicable	C57BL/6 mice	Selenium	GPX4	[92]
	In vivo	Not applicable	Sprague–Dawley rats	Liproxstatin-1, Ferrostatin-1	Not available	[95]
	In vivo	Not applicable	Brain I/R mice model	Carthamin yellow	Not available	[96]
	In vivo	Not applicable	Mice models of cerebral I/R	MiR-214	PVT1, TFR1, TP53	[97]
	In vivo	Not applicable	Ischemic stroke model gerbils	Carvacrol	GPX4	[98]
	In vivo	Not applicable	Ischemic stroke model gerbils	Galangin	SLC7A11, GPX4	[100]
	In vivo	Not applicable	Mice models	Knockdown of ACSL4	Not available	[102]
Ischemic renal injury	In vivo	Not applicable	C57BL/6 mice	Ferrostatin 1 or 16–86	Not available	[106]
	In vivo	Not applicable	I/R-induced renal injury rat models	Not available	GPX4, SLC7A11	[107]
	In vivo	Not applicable	Mice models	PANX1 deletion	Not available	[108]
	In vivo	Not applicable	Mif-/- mice	MIF	GSH	[109]
	In vivo	Not applicable	Renal I/R injury mice model	Pachymic acid	GPX4, SLC7A11, and HO-1	[110]
	In vivo	Not applicable	Renal I/R mice model	XJB-5-131	Not available	[111]
	In vivo	Not applicable	Renal I/R mice model	Irisin	GPX4	[112]
Hepatic I/R injury	In vivo	Not applicable	Gpx4-/- mice	Knockout of GPX4	Not available	[6]
	In vivo	Not applicable	Murine hepatic I/R injury model	Iron overload	Not available	[116]
Intestinal I/R injury	In vitro	Not applicable	Caco-2 cells	Rosiglitazone, si-special protein 1	ACSL4	[117]
	In vitro	Not applicable	Ileum organoid H/R model	Capsiate	GPX4, TRPV1	[119]
	In vivo	Not applicable	Murine model of intestinal I/R	Rosiglitazone, si-special protein 1	ACSL4	[117]
	In vivo	Not applicable	Mouse intestinal I/R model	Capsiate	GPX4, TRPV1	[119]
Acute lung injury induced by intestinal I/R	In vivo	Not applicable	C57BL/6J mice and Nrf2-/- mice	Nrf2	SLC7A11, HO-1	[122]
	In vivo	Not applicable	Nrf2-/- mice with acute lung injury induced by intestinal I/R	Inhibitor of apoptosis-stimulating protein of P53	Nrf2	[123]