Jie-Yu-He-Huan Capsule Ameliorates Anxiety-Like Behaviours in Rats Exposed to Chronic Restraint Stress via the cAMP/PKA/CREB/BDNF Signalling Pathway

Figure 9

Schematic of the possible mechanism underlying the anxiolytic effect of the Jie-Yu-He-Huan capsule. The Chinese medicine formula Jie-Yu-He-Huan can ameliorate anxiety-like behaviours in rats exposed to chronic restraint stress by normalising the overactivated HPA axis function, ultimately regulating the 5-HT system, and finally targeting the cAMP-PKA-CREB-BDNF signalling pathway. HPA: hypothalamic–pituitary–adrenal; JYHH: Jie-Yu-He-Huan capsule; CRS: chronic restraint stress; CRH: corticotropin-releasing hormone; ACTH: adrenocorticotropic hormone; GR: glucocorticoid receptor; CORT: corticosterone; PFC: prefrontal cortex; 5-HT: 5-hydroxytryptamine; 5-HT1AR: 5-HT1A receptor; cAMP: cyclic adenosine monophosphate; PKA: protein kinase A; CREB: cAMP response element-binding protein; BDNF: brain-derived neurotrophic factor.