Enhanced Expression of miR-34a Enhances <i>Escherichia coli</i> Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NF-<i>κ</i>B Pathway

<div>Inhibition of miR-34a enhances the expression of LGR4 in LPS-treated mice. (a) Schematic illustration of intrauterine injection of miR-34a antagomir or negative control. (b) H&amp;E pathological analysis was conducted to identify a mouse model of endometrial inflammation (HE, <span class="nowrap"><svg height="8.69875pt" id="M77" style="vertical-align:-0.3499298pt" version="1.1" viewbox="-0.0498162 -8.34882 26.5494 8.69875" width="26.5494pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M528 54L331 254L528 455L492 493L294 291L96 493L60 455L257 254L60 54L96 16L294 217L492 16L528 54Z"></path></g><g transform="matrix(.013,0,0,-0.013,7.631,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z"></path></g><g transform="matrix(.013,0,0,-0.013,13.871,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 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(d, e) Western blotting was used to determine the LGR4 protein level. Grey values of the indicated proteins were measured by ImageJ software. 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Comparisons among multiple groups were analysed by one-way analysis of variance with the Bonferroni posttest.</div>

Oxidative Medicine and Cellular Longevity

fig9

Figure 9

Figure 9: Enhanced Expression of miR-34a Enhances <i>Escherichia coli</i> Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NF-<i>κ</i>B Pathway 

Figure 9 | Enhanced Expression of miR-34a Enhances Escherichia coli Lipopolysaccharide-Mediated Endometritis by Targeting LGR4 to Activate the NF-κB Pathway 