Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells

<div>P53 inactivation upregulates SLC7A11 to alleviate bavachin-induced ferroptosis in osteosarcoma (OS) cells. OS cells were pretreated with pifithrin-<i>α</i> (PFT-<i>α</i>, 5 <i>μ</i>M) followed by treatment with bavachin (40 <i>μ</i>M, 24 h). (a, b) Western blotting shows the relative levels of P53, SLC7A11, and GPX4 protein expression. (c) PFT-<i>α</i> (5 <i>μ</i>M) restores bavachin-induced GSH depletion. (d, e) PFT-<i>α</i> reduces bavachin-induced ROS and MDA accumulation. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: Bavachin Induces Ferroptosis through the STAT3/P53/SLC7A11 Axis in Osteosarcoma Cells 