Effect of Metformin on Locomotor Function Recovery in Rat Spinal Cord Injury Model: A Meta-analysis

Table 2

Risk of bias in included studies accessed by SYRCLE’s RoB tool.

Study

Risk of bias for each item assessed

Selection bias

Performance bias

Detection bias

Attrition bias

Reporting bias

Other biases

1

2

3

4

5

6

7

8

9

10

11

12

13

14

Afshari et al. (2018)

Unclear

Yes

Unclear

Yes

Unclear

Unclear

Yes

Unclear

Yes

Unclear

Unclear

Yes

Yes

Unclear

Guo et al. (2018)

Unclear

Yes

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Yes

Unclear

Unclear

Yes

Yes

Unclear

Wang et al. (2016)

Unclear

Yes

Unclear

Unclear

Unclear

Unclear

Yes

Unclear

Yes

Unclear

Unclear

Yes

Yes

Yes

Wang et al. (2020)

Unclear

Yes

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Yes

Unclear

Unclear

Yes

Yes

Unclear

Zhang et al. (2017a)

Unclear

Yes

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Yes

Yes

Unclear

Yes

Yes

Unclear

Zhang et al. (2017b)

Unclear

Yes

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Yes

Yes

Unclear

Yes

Yes

Unclear

Zhang et al. (2020)

Yes

Yes

Unclear

Unclear

Unclear

Unclear

Unclear

Unclear

Yes

Unclear

Unclear

Yes

Yes

Unclear

1: sequence generation; 2: baseline characteristics; 3: allocation concealment; 4: random housing; 5: blinding; 6: random outcome assessment; 7: blinding; 8: complete outcome data; 9: selective outcome reporting; 10: free of contamination; 11: free of inappropriate influence of funders; 12: free of the unit of analysis errors; 13: design-specific risks of bias absent; 14: new animals added to replace drop-outs.