PPARα Targeting GDF11 Inhibits Vascular Endothelial Cell Senescence in an Atherosclerosis Model

Figure 1

PPARα inhibits atherosclerotic plaque formation and vascular endothelial injury. (a) HE staining showed that PPARα agonists inhibited AS plaque formation. (b) Masson’s trichrome staining showed that PPARα agonists promoted plaque stability in the Apoe^-/- mouse model. (c) The PPARα agonist made the surface of aortic plaque covered with intact endothelial cells and inhibited endothelial cell apoptosis and necrosis. ^{, #}, ^##, : vs. control, #: vs. model. Scale bar, 5 μm or 10 μm or 20 μm.

(a)

(b)

(c)