H2A.X Phosphorylation in Oxidative Stress and Risk Assessment in Plasma Medicine

Figure 1

Isoform histone H2A.X in the context of the chromatin structure. The nucleosome is made up of approximately 147 base pairs of DNA around a histone octamer. The core particle can contain instead of H2A.1-H2A.2 two proteins of H2A.X (H2A.X₂) that are extended c-terminally by the SQEY-motif of 22 amino acids. The functional group of the posttranslational phosphorylation to γH2A.X is the hydroxyl group (-OH) of the serine at position 139. Model adapted according to [44].