Research Article
The Effect of Berberine on Metabolic Profiles in Type 2 Diabetic Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Table 1
Specific characteristics of included trials.
| Study | Participants | No. (T/C) | Age | Sex (M/F) | Course (year) | Intervention | Control | Duration (weeks) | Outcomes |
| Zhang et al. 2020 [15] | T2DM | 98/103 | T: 53 (42–61) C: 54 (46–61) | T: 59/39 C: 61/42 | Newly diagnosed | Berberine 0.5 g bid | Placebo | 12 | ①②③④⑤⑥⑦⑧⑨⑩ | Hu 2020 [28] | T2DM | 60/58 | T: C: | T: 34/26 C: 30/28 | T: C: | Berberine 0.3 g tid Metformin 0.5 g tid | Placebo Metformin 0.5 g tid | 24 | ①③④⑤⑥⑦⑧⑨⑩ | Sanjari et al. 2020 [26] | T2DM | 42/38 | T: C: | T: 18/24 C: 7/31 | T: C: | Berberis integerrima root extract 480 mg | Metformin 1 g/d | 12 | ①②③⑥⑦⑧⑨ | Li et al. 2021 [20] | Prediabetes | 35/35 | T: C: | T: 22/13 C: 17/18 | — | Berberine 0.3 g tid | Life intervention | 24 | ①②③⑥⑦⑧⑨⑩ | Tahmasebi et al. 2019 [27] | T2DM | 40/40 | T: C: | T: 17/23 C: 15/25 | Less than 10 years | 1000 mg dry extract and 157.3 mg berberine | Placebo | 6 | ①②④⑥⑦⑧⑨⑩ | Ma 2019 [24] | T2DM | 50/50 | T: C: | T: 31/19 C:28/22 | T: C: | C+Huanglian 3 g tid | Metformin 0.5 g tid | 8 | ①②③④⑥⑦⑧⑨ | Deng et al. 2019 [29] | T2DM | 35/35 | T: C: | T:23/12 C:21/14 | T: C: | C+berberine 0.3 g tid | Glipizide 5 mg tid | 12 | ①②③④⑥⑦⑧⑨ | Chen et al. 2018 [30] | T2DM | 40/40 | T: C: | T: 22/18 C: 24/16 | T: C: | C+berberine 0.5 g tid | Metformin 0.5 g tid | 12 | ①②③⑩ | Wu 2018 [31] | T2DM | 63/63 | T: C: | T: 37/26 C: 38/25 | NA | C+berberine 0.2 g tid | Metformin 0.5 g tid | 12 | ①②③⑤⑥⑦⑧⑨⑩ | Rashidi et al. 2018 [32] | T2DM | 40/41 | T: C: | T: 14/28 C: 19/22 | T: C: | Berberine 0.5 g bid | Placebo | 4 | ①②④⑥⑦⑧⑨⑩ | Li et al. 2018 [33] | T2DM | 57/57 | T: C: | T: 22/35 C: 24/33 | T: 5.92 (1.92, 8) C:7.25 (2, 10.2) | C+berberine 300 mg tid | Antidiabetic agents | 24 | ①②③⑤⑥⑦⑩ | Sha et al. 2018 [34] | T2DM | 30/30 | T: C: | T: 15/13 C: 14/15 | T: C: | Berberine 500 mg tid | NA | 12 | ①③④⑩ | Zhao 2018 [22] | Prediabetes | 32/32 | T: C: | T: 24/8 C: 26/6 | — | Berberine 0.3-0.5 g tid | Life intervention | 12 | ①②③⑤⑥⑦ | Guan et al. 2017 [35] | T2DM | 53/53 | T: C: | T: 29/24 C: 28/25 | T: C: | C+berberine 0.5 g tid | Metformin 0.5 g tid | 4 | ①③ | Zhang 2017 [36] | T2DM | 40/40 | T: C: | T: 21/19 C: 23/17 | T: C: | Berberine 3 g tid | Metformin 750 mg/d | 12 | ①②③④ | | | 40/40 | T: C: | T:22/18 C:23/17 | T: C: | C+berberine 3 g tid | Metformin 750 mg/d | 12 | ①②③④ | Xing 2017 [37] | T2DM | 35/35 | T: C: | T: 18/17 C: 17/18 | T: C: | Berberine 500 mg tid | Metformin 250 mg tid | 12 | ①③④⑤⑥⑦⑧⑨⑩ | Sun 2017 [38] | T2DM | 91/91 | T: C: | T: 53/38 C: 51/40 | T: C: | C+berberine 30 mg tid | Metformin 0.5 g tid | 8 | ①②③④⑥⑦⑧⑨⑩ | Chen et al. 2017 [39] | Prediabetes | 50/50 | T: C: | T: 31/19 C: 30/20 | — | Berberine 0.5 g tid | Metformin 0.5 g tid | 24 | ①②⑤ | Li et al. 2017 [40] | T2DM | 30/30 | T: C: | T: 18/12 C: 17/13 | T: C: | C+berberine 0.3 g tid | Sitagliptin 100 mg tid | 12 | ①②③ | Li 2016 [41] | T2DM | 90/90 | T: C: | T: 55/35 C: 55/35 | T: C: | C+berberine 0.3 g tid | Metformin 1.7 g/d | 12 | ①②③④ | Lang and Zhu 2016[42] | T2DM | 50/50 | | 63/37 | NA | Berberine 500 mg tid | Placebo | 12 | ①②③ | Du 2016 [43] | T2DM | 37/36 | T: C: | T: 21/16 C: 18/18 | T: C: | C+berberine 4 pills tid | Metformin 0.5 g tid | 4 | ①②③ | Li 2016 [44] | T2DM | 60/60 | T: C: | T: 26/24 C: 28/32 | T: C: | C+berberine 0.5 g tid | Glipizide 5 mg tid | 12 | ③④⑥⑦⑧⑨ | Cui 2016 [45] | T2DM | 40/40 | T: C: | T: 28/12 C: 30/10 | T: C: | C+berberine 0.5 g tid | Metformin 0.5 g tid | 16 | ①②③⑥⑦ | Ren et al. 2016 [46] | T2DM | 31/30 | T: C: | T: 21/10 C: 19/11 | Newly diagnosed | C+berberine 0.5 g tid | Life interverntion | 12 | ①②③⑥⑦⑧⑨ | Wang 2015 [25] | T2DM | 39/36 | T: C: | T: 22/17 C: 21/15 | T: C: | C+Huanglian 3 g tid | Metformin 0.5 g tid | 8 | ①②③④⑥⑦⑧⑨ | Yu 2015 [47] | T2DM | 49/48 | T: C: | T: 23/26 C: 25/23 | T: C: | C+berberine 0.5 g tid | Metformin 0.5 g qd | 12 | ①③⑥⑦ | Zhu et al. 2015 [48] | T2DM | 59/59 | T: C: | T: 35/24 C: 33/26 | T: y C: | C+berberine 100 mg tid | Gliclazide modified release tablets 30 mg qd | 12 | ①②③⑥⑦⑧⑨ | Shu 2014 [49] | T2DM | 32/32 | T: C: | T: 19/13 C: 20/12 | T: C: | C+berberine 300 mg tid | Metformin 0.5 g tid | 24 | ①④ | Zhou 2014 [50] | T2DM | 33/33 | | 46/20 | | C+berberine 300 mg tid | Metformin 0.5 g bid | 12 | ①②③⑤⑥⑦⑧⑨ | Cao 2012 [51] | T2DM | 38/40 | T: C: | T: 22/16 C: 24/16 | Newly diagnosed | C+berberine 0.5 g tid | Metformin 0.5 g tid | 16 | ①②③④⑤⑥⑦⑧⑨⑩ | Zhou and Huang 2012 [52] | T2DM | 45/45 | | 48/44 | | C+berberine 0.5 g tid | Metformin 0.5 g tid | 12 | ①②④⑤⑥⑦⑧⑨ | Zhang and Yuan 2012 [53] | T2DM | 38/38 | No difference | T: 21/17 C: 20/18 | No difference | C+berberine 0.5 g-0.8 tid | Metformin 0.5 g tid | 12 | ①②③ | Xue et al. 2012 [54] | T2DM | 44/45 | No difference | No difference | No difference | C+berberine 0.5 g tid | Metformin 1.5 g/d SU | 12 | ①②③④ | Lou et al. 2011 [55] | T2DM | 30/30 | 36-74 | 32/28 | Newly diagnosed | C+berberine 0.3 g tid | Metformin 1.5 g/d | 24 | ①②③④⑥⑦⑧⑨ | Qiu et al. 2011 [56] | T2DM | 49/51 | T: C: | T: 26/23 C: 28/23 | NA | C+berberine 0.3 g tid | Antidiabetic drugs | 8 | ①②③④⑩ | Meng et al. [57] 2011 | T2DM | 30/30 | T: C: | T: 17/13 C: 16/14 | Newly diagnosed | C+berberine 0.3 g tid | Insulin injection | 12 | ①②③ | Ye 2010 [58] | T2DM | 40/40 | T: C: | T: 24/16 C: 22/18 | T: C: | C+berberine 0.5 g tid | Glimepiride 0.1 mg bid Metformin 0.5 g tid | 12 | ①②③⑤⑥⑦⑧⑨ | Sheng and Xie 2010 [59] | T2DM | 30/30 | T: C: | T: 18/12 C: 11/19 | T: C: | C+berberine 0.5 g tid | Glipizide 5 mg bid Metformin 0.5 g tid | 12 | ①④⑤⑩ | Xu et al. 2008 [60] | T2DM | 32/32 | | 34/30 | Newly diagnosed | C+berberine 0.3 g tid | Pioglitazone 30 mg qd | 12 | ①②⑦ | Zhang et al. 2008 [61] | T2DM | 59/57 | T: C: | T: 30/28 C: 31/21 | Newly diagnosed | Berberine 0.5 g bid | Placebo | 12 | ①②③④⑤⑥⑦⑧⑨⑩ | Li et al. 2008 [62] | T2DM | 33/32 | T: 47.5 C: 49.2 | T: 17/16 C: 16/16 | T: C: | Berberine 500 mg tid | Metformin 250 mg tid | 12 | ①②③④⑤⑥⑦⑧⑨⑩ | Liu and Hu 2008 [63] | T2DM | 30/30 | T: C: | T: 10/20 C: 14/16 | T: C: | C+berberine 0.3-0.5 g tid | Metformin 500 mg tid | 8 | ①②③④ | Ju et al. 2007 [23] | Prediabetes | 46/44 | T: C: | T: 28/18 C: 26/18 | — | Berberine 0.6 g/d | NA | 48 | ①②⑤⑥⑦⑧⑨⑩ | Zhang 2005 [64] | T2DM | 48/46 | | 50/44 | 6-10 | SU+berberine 0.3 g tid | Metformin 1.5 g/d + SU | 12 | ①②③④ | Cao 2004 [65] | T2DM | 30/30 | T: C: | T: 13/17 C: 12/18 | T: C: | Berberine 0.5 g tid Life intervention | Life intervention | 12 | ①②③④⑤⑥⑦⑧⑨⑩ |
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Note: ① FBG: fasting blood glucose; ② 2hPBG: 2-hour postprandial blood glucose; ③ HbA1c: glycated hemoglobin; ④ FINS: fasting insulin; ⑤ BMI: body mass index: ⑥ TC: total cholesterol; ⑦ TG: triglyceride; ⑧ HDL-C: high-density lipoprotein cholesterol; ⑨ LDL-L: low-density lipoprotein cholesterol; ⑩HOMA-IR.
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