Vascular Ageing Features Caused by Selective DNA Damage in Smooth Muscle Cell

Figure 4

Vasorelaxation in aortic rings of SMC-KO and WT mice for both time-points in response to ACh (10^-9 to 10^-5 mol/L) (a). The contribution of NO-cGMP and EDH pathway in WT ET (b), WT LT (c), SMC-KO ET (d), and SMC-KO LT (e). Vasorelaxation in aortic rings of SMC-KO and WT mice for both time-points in response to SNP (10^-11 to 10^-4 mol/L) (f), SNP (0.1 mmol/L) after ACh CRC (g), and ACh (10^-9 to 10^-5 mol/L) corrected to SNP (0.1 mmol/L) (h). The number in each column represents the number of animals in the corresponding group. Statistical differences were analyzed by general linear model repeated measures for (a–f) and (h) and two-way ANOVA followed by Bonferroni’s post hoc test for (g) ().

(a)

(b)

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(e)

(f)

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(h)