SIRT1 Attenuates Apoptosis of Nucleus Pulposus Cells by Targeting Interactions between LC3B and Fas under High-Magnitude Compression

Figure 7

Schematic diagram showing the potential mechanism by which SIRT1 upregulation modulates high-magnitude compression-induced NPC apoptosis in this study. NP cell apoptosis is a main cellular pathological feature during IDD, which ultimately contributes to aggravation of IDD. In this study, our result demonstrated that upregulation of SIRT1 expression increased formation of the LC3B/Fas complex, which contributed to suppression of NPC apoptosis under high-magnitude compression via inhibition of the NF-κB pathway. IDD: intervertebral disc degeneration.