The Preventive Effect of Cardiac Sympathetic Denervation Induced by 6-OHDA on Myocardial Ischemia–Reperfusion Injury: The Changes of lncRNA/circRNAs-miRNA-mRNA Network of the Upper Thoracic Spinal Cord in Rats

Figure 6

Validation of lncRNAs and mRNAs by RT-qPCR in the T1–T4 spinal cord IR group and SD-IR group. (a) The expression levels of lncRNA NONRATT012797.2 and NONRATT029190.2 were significantly upregulated in SD-IR group, whereas the expression levels of lncRNA NONRATT000247.2, NONRATT004098.2, and NONRATT025664.2 were significantly downregulated in SD-IR group. (b) The expression levels of mRNA Ubd, Ccl12, and Cxcl10 were significantly upregulated in SD-IR group, whereas the expression levels of mRNA LOC100912599 and Dpep1 were significantly downregulated in SD-IR group. (c) The expression levels of five lncRNAs and five mRNAs. Two upregulated lncRNAs, three downregulated lncRNAs, three upregulated mRNAs, and two downregulated mRNAs were validated by RT-qPCR. Data are expressed as mean ± SEM. , , vs. IR group.

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