Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm

Figure 1

CIH exposure increases AAA incidence. An animal model of AAA was established by infusion Apoe^-/- mice with Ang II. The mice in the control group were infused with the same volume of saline. Mice were then exposed to CIH condition for 4 weeks. (a) Representative image of the whole aortae. (b) Representative ultrasound images. (c) The incidence of AAA (). (d) Maximal abdominal aortic diameter (-10). (e) Survival rate of mice in each group (). (f) Representative image of elastic Van Gieson (EVG) staining. (g) Score of elastin degradation from EVG staining (-10). , .

(a)

(b)

(c)

(d)

(e)

(f)

(g)