Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm

Figure 2

CIH upregulates AAA-related expression of MMP protein in vivo. An animal model of AAA was established by infusion Apoe^-/- mice with Ang II. The mice in the control group were infused with the same volume of saline. Mice were then exposed to CIH condition for 4 weeks. (a) Representative image of immunohistochemical. Quantification of (b) MMP2-, (c) MMP9-, and (d) α-SMA-positive area from immunohistochemical (). (e) Representative image of Western blot. (f) Quantification of MMP2, MMP9, and MCP1 protein expressions (). (g) MMP2 and MMP9 activities by zymography. (h) Quantification of MMP2 and MMP9 activities (). , , and .

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