Research Article
Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells
Figure 5
Effect of Rosolic acid against ER stress as assessed by ER stress markers such as (a) protein kinase R- (PKR-) like endoplasmic reticulum kinase (PERK), (b) activating transcription factor- (ATF-) 6, (c) glucose-regulated protein (GRP) 78, and (d) C/ERB homologous protein (CHOP) expression in ER stress-induced EA.hy926 cells qRT-PCR analysis. (e) The effect of Rosolic acid on GRP-78 and CHOP by western blotting in EA.hy926 cells under ER stress. Data are represented as of three independent experiments. Significant compared with the control group. #Significant compared with TPG group; determined by one-way ANOVA followed by Tukey’s post hoc test.
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