Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells

Table 3

List of DAVID annotation clusters with enrichment score above 10.

Enrichment score: 17.2
Category	Term	Count	value	Fold enrichment	Bonferroni	Benjamini	FDR
Annotation cluster 1
GOTERM_MF_DIRECT	Cadherin binding involved in cell-cell adhesion	33	2.1E-19	7.9	9.1E-17	3.0E-17	3.0E-16
GOTERM_CC_DIRECT	Cell-cell adherens junction	33	5.3E-19	7.7	2.1E-16	3.0E-17	7.4E-16
GOTERM_BP_DIRECT	Cell-cell adhesion	28	2.2E-15	7.2	3.5E-12	1.8E-12	3.7E-12
Enrichment score: 13.35
Annotation cluster 2
UP_KEYWORDS	Chaperone	32	1.4E-25	13.3	3.6E-23	1.2E-23	1.8E-22
GOTERM_MF_DIRECT	Unfolded protein binding	26	3.1E-23	16.4	1.3E-20	6.5E-21	4.3E-20
GOTERM_BP_DIRECT	Protein folding	30	2.4E-22	11.6	3.8E-19	3.8E-19	4.0E-19
UP_KEYWORDS	Stress response	22	1.4E-20	18.4	3.6E-18	6.0E-19	1.8E-17
INTERPRO	Heat shock protein Hsp90	10	5.4E-16	68.9	2.7E-13	2.7E-13	8.0E-13
INTERPRO	Heat shock protein Hsp90, N-terminal	8	2.2E-12	67.3	1.1E-9	5.3E-10	3.1E-9
INTERPRO	Ribosomal protein S5 domain 2-type fold	12	8.5E-12	20.7	4.1E-9	6.8E-10	1.2E-8
GOTERM_BP_DIRECT	Response to stress	12	9.4E-10	13.7	1.5E-6	1.4E-7	1.6E-6
INTERPRO	Histidine kinase-like ATPase, ATP-binding domain	9	8.3E-9	20.7	4.0E-6	3.3E-7	1.2E-5
SMART	HATPase_c	6	8.9E-8	46.1	8.5E-6	8.5E-6	9.8E-5
INTERPRO	Heat shock protein Hsp90, conserved site	4	8.9E-6	75.8	4.3E-3	2.2E-4	1.3E-2
PIR_SUPERFAMILY	Heat shock protein, HSP90/HTPG types	4	7.9E-5	35.2	2.4E-3	2.4E-3	6.7E-2
Enrichment score: 10.88
Annotation cluster 3
UP_KEYWORDS	GTP-binding	30	1.1E-16	7.3	2.9E-14	4.1E-15	1.4E-13
UP_SEQ_FEATURE	Nucleotide phosphate-binding region: GTP	28	1.1E-15	7.4	8.7E-13	8.7E-13	1.7E-12
UP_KEYWORDS	Nucleotide-binding	64	2.0E-15	3.0	5.1E-13	6.4E-14	2.6E-12
GOTERM_MF_DIRECT	GTPase activity	26	5.4E-15	7.7	2.3E-12	4.5E-13	7.5E-12
GOTERM_MF_DIRECT	GTP binding	32	6.5E-15	5.8	2.7E-12	4.6E-13	9.1E-12
INTERPRO	Small GTP-binding protein domain	19	8.0E-12	8.6	3.8E-9	7.6E-10	1.1E-8
UP_KEYWORDS	Prenylation	18	1.9E-11	9.0	4.8E-9	4.3E-10	2.4E-8
UP_SEQ_FEATURE	Lipid moiety-binding region: S-geranylgeranyl cysteine	15	5.1E-11	11.4	4.0E-8	2.0E-8	7.8E-8
UP_SEQ_FEATURE	Short sequence motif: effector region	14	2.8E-10	11.4	2.2E-7	7.3E-8	4.3E-7
INTERPRO	P-loop containing nucleoside triphosphate hydrolase	38	3.5E-10	3.3	1.7E-7	2.1E-8	5.0E-7
INTERPRO	Small GTPase superfamily	15	4.3E-9	8.2	2.1E-6	1.9E-7	6.2E-6
GOTERM_BP_DIRECT	Small GTPase-mediated signal transduction	19	1.7E-8	5.4	2.8E-5	1.7E-6	2.9E-5
GOTERM_MF_DIRECT	GDP binding	9	9.7E-7	11.5	4.1E-4	3.4E-5	1.4E-3
UP_KEYWORDS	Lipoprotein	27	1.1E-5	2.7	2.9E-3	1.1E-4	1.5E-2