Research Article
Pharmacological Activation of Nrf2 by Rosolic Acid Attenuates Endoplasmic Reticulum Stress in Endothelial Cells
Table 4
List of DAVID–KEGG pathways of differentially regulated proteins.
| | Term | Count | % | value | Fold enrichment | Bonferroni | Benjamini | FDR |
| | Protein processing in endoplasmic reticulum | 26 | 10.6 | 3.6E-14 | 6.7 | 6.0E-12 | 6.0E-12 | 4.3E-11 | | Endocytosis | 20 | 8.1 | 1.8E-6 | 3.6 | 3.1E-4 | 7.8E-5 | 2.2E-3 | | RNA transport | 17 | 6.9 | 1.5E-6 | 4.3 | 2.5E-4 | 8.3E-5 | 1.8E-3 | | Proteasome | 9 | 3.7 | 5.2E-6 | 9.0 | 8.7E-4 | 1.8E-4 | 6.3E-3 | | Antigen processing and presentation | 9 | 3.7 | 3.0E-4 | 5.2 | 4.9E-2 | 8.4E-3 | 3.6E-1 | | Phagosome | 12 | 4.9 | 5.7E-4 | 3.5 | 9.1E-2 | 1.1E-2 | 6.9E-1 | | Estrogen signaling pathway | 9 | 3.7 | 1.7E-3 | 4.0 | 2.6E-1 | 2.9E-2 | 2.1E0 | | Leukocyte transendothelial migration | 9 | 3.7 | 4.4E-3 | 3.4 | 5.3E-1 | 6.6E-2 | 5.3E0 | | Adherent junction | 6 | 2.4 | 2.2E-2 | 3.7 | 9.8E-1 | 1.9E-1 | 2.4E1 | | AMPK signaling pathway | 8 | 3.3 | 2.1E-2 | 2.8 | 9.7E-1 | 1.9E-1 | 2.3E1 | | Rap1 signaling pathway | 11 | 4.5 | 2.1E-2 | 2.3 | 9.7E-1 | 2.0E-1 | 2.3E1 | | Regulation of actin cytoskeleton | 10 | 4.1 | 4.9E-2 | 2.1 | 1.0E0 | 3.5E-1 | 4.6E1 | | Pathways in cancer | 15 | 6.1 | 6.2E-2 | 1.7 | 1.0E0 | 3.5E-1 | 5.4E1 | | Sphingolipid signaling pathway | 7 | 2.8 | 5.5E-2 | 2.6 | 1.0E0 | 3.5E-1 | 5.0E1 | | Pyruvate metabolism | 4 | 1.6 | 6.1E-2 | 4.4 | 1.0E0 | 3.6E-1 | 5.4E1 | | Cysteine and methionine metabolism | 4 | 1.6 | 5.4E-2 | 4.6 | 1.0E0 | 3.6E-1 | 4.9E1 | | Platelet activation | 7 | 2.8 | 7.5E-2 | 2.4 | 1.0E0 | 3.8E-1 | 6.1E1 | | Endocrine and other factor-regulated calcium reabsorption | 4 | 1.6 | 8.1E-2 | 3.9 | 1.0E0 | 3.9E-1 | 6.4E1 | | Nucleotide excision repair | 4 | 1.6 | 9.0E-2 | 3.7 | 1.0E0 | 4.0E-1 | 6.8E1 |
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