Research Article
Antifungal Treatment Aggravates Sepsis through the Elimination of Intestinal Fungi
Figure 2
Antifungal treatment augmented cytokine production and aggravated organ injury. (a, b) Serum cytokine levels were determined by LEGENDplex™ assays 2 hours post lipopolysaccharide (LPS) challenge (a) or before LPS challenge (b), per group. (c, d) Representative fields of view from hematoxylin and eosin-stained sections showed the lung (c) and liver (d) tissue of mice at the 14th day of fluconazole treatment versus water treatment control on steady state (S.S.) or 10 hours post-LPS challenge. The black arrow indicates the tissue damage or immune cell infiltration. Scale bar represents 20 μm. Two group comparisons were conducted with a standard two-tailed unpaired Student’s -test (a, b).
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