Antifungal Treatment Aggravates Sepsis through the Elimination of Intestinal Fungi

Figure 3

Antifungal treatment aggravated sepsis model via fungal microbiota. (a) Survival curve of germ-free mice in water drinking (control) or fluconazole drinking group in challenge of lipopolysaccharide (LPS), per group. (b) Serum level of cytokines of germ-free mice at 10 hours post-LPS challenge of the two groups, per group. (c) Survival curve of antibiotics- (abx-) treated and abx plus fluconazole treated mice. per group. Data were from one of two independent experiments (c). Two group comparisons were conducted with a standard two-tailed unpaired Student’s -test (b). Mortality was compared by Kaplan-Meier survival curves and analyzed by the log-rank (Mantel-Cox) test (a, c).

(a)

(b)

(c)