Broussochalcone A Induces Apoptosis in Human Renal Cancer Cells via ROS Level Elevation and Activation of FOXO3 Signaling Pathway

Figure 8

Comet assay was performed to identify BCA induces DNA damage in (a) A498 and (b) ACHN cells. The cells were treated with BCA (0, 10, and 20 μM) of 48 h. BCA-induced DNA damage was investigated using a comet assay. As shown, the length of comet tail dose-dependently enhanced in response to (0, 10, and 20 μM) BCA treatment. (c, d) The bar graph indicated the length of comet tail increased significantly. Significant differences between BCA treat and DMSO control groups are indicated as ( means ).

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