[Retracted] Styrylchromones: Biological Activities and Structure-Activity Relationship

Table 9

2-SC studied for the anti-inflammatory activity and summary of the observed anti-inflammatory effects.

2-SC	Observed effect(s)	Ref.
1	Inhibition of LTB4 production in human neutrophils	[54]
5
11	Inhibition of LTB4 production in human neutrophils and COX-1 activity
15	Inhibition of LTB4 production in human neutrophils, NF-kB activation and production of TNF-α and IL-6; and induction of the production of IL-1β and IL-8	[54, 59]
16	Inhibition of LTB4 production in human neutrophils; and reducing activity	[54]
17	Inhibition of LTB4 production in human neutrophils; metal chelating capacity; reducing activity; inhibition of NF-kB activation and production of TNF-α, IL-1β, IL-6 and IL-8	[54, 59]
18, 19	Inhibition of LTB4 production in human neutrophils and COX-1 activity; metal chelating capacity; and reducing activity	[54]
20	Inhibition of LTB4 production in human neutrophils; metal chelating capacity; and reducing activity
21	Inhibition of LTB4 production in human neutrophils, NF-kB activation and production of TNF-α, IL-1β and IL-6	[54, 59]
33	Inhibition of cell-cell adhesion between HL-60 cells and CHO-ICAM-1 cells	[52]

CHO: Chinese hamster ovary; COX-1: cyclooxygenase-1; HL-60: promyelocytic human leukaemia-60; ICAM-1: intercellular cell adhesion molecule-1; IL: interleukin; LT: leukotriene; NF-κB: nuclear factor kappa B; TNF-α: tumor necrosis factor α.