ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3

Figure 5

ULK1 activation alleviates bone loss in vivo. (a) Schematic diagram of treatment of OVX mice. (b) Representative μCT images (scale bars, 0.5 mm). (c) Quantification of cortical bone parameters by μCT from sham, therapy, and control mice. Tb. Sp; Tb. N; Tb. Th; BV/TV; BMD (). (d) H&E staining of femur sections from sham, OVX, and OVX mice treated with LYN-1604 therapy (scale bar, 100 μm). (e) TRAP staining of femur sections from sham, OVX, and OVX with LYN-1604 therapy. The yellow arrowhead points to OC (scale bar, 100 μm). (f) Immunohistochemistry of ULK1 in femur sections from OVX mice treated with vehicle and LYN-1604 (scale bar, 100 μm). (g) Immunohistochemistry of p-JNK in femur sections from OVX mice treated with vehicle and LYN-1604 (scale bar, 100 μm). All data are ; , , .

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