CGRP Regulates Nucleus Pulposus Cell Apoptosis and Inflammation via the MAPK/NF-κB Signaling Pathways during Intervertebral Disc Degeneration

Figure 6

CGRP induced the activation of NF-κB and MAPK signaling pathways. (a, b) CGRP dose-dependently promoted the phosphorylation of MAPK (p38, ERK, and JNK). (c, d) NF-κB signaling pathway was also concentration-dependently activated by CGRP, and this activated effect was achieved through the phosphorylation of IκB-α. (e) Immunofluorescence results suggested that the nucleus translocation of p65 was increased when human NP cells were treated with CGRP. , , , and ; ns: no significance.  μm.

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