CGRP Regulates Nucleus Pulposus Cell Apoptosis and Inflammation via the MAPK/NF-κB Signaling Pathways during Intervertebral Disc Degeneration

Figure 8

Evaluation of the therapeutic effects of Rimegepant on injury-induced IVDD in vivo. (a, b) The intervertebral disc was degenerated significantly in the injury group, whereas this effect was alleviated by Rimegepant administration. (c, d) Immunohistochemical analysis revealed that mice in the injury+Rimegepant group showed higher protein translation of type II collagen compared to those in the injury group. ^/#, ^/##, ^/###, and ^/####; ns: no significance.

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