Oxidized LDL Is Associated with eGFR Decline in Proteinuric Diabetic Kidney Disease: A Cohort Study
Table 1
Baseline anthropometric, clinical, and biochemical data of patients with diabetic kidney disease, below and above median plasma oxidized LDL levels. Results for continuous variables are presented as mean (S.D.) or median (range).
()
()
All patients ()
Age (years)
0.33
Gender (M/F)
20/26
23/22
43/48
0.30
Smoking habit (%)
19%
26.6%
23,1%
0.29
History of CV disease (%)
65%
75.5%
70.3%
0.20
Duration of T2DM (years)
12 (7-35)
14 (7-34)
13 (7-35)
0.18
BMI (kg/m2)
0.46
SBP (mm Hg)
137.5 (100-180)
140 (119-180)
140 (100-180)
0.14
DBP (mm Hg)
77.5 (50-90)
80 (60-95)
80 (50-95)
0.04
Hemoglobin (g/dl)
12.8 (8.8-16.2)
12.4 (7.3-15.9)
12.6 (7.3-16.2)
0.42
HbA1c (%)
7.1 (5.6-10.2)
7.3 (5.0-11.6)
7.2 (5.0-11.6)
0.23
Albumin (g/dl)
4.3 (3.4-4.9)
4.3 (3.2-5.0)
4.3 (3.2-5.0)
0.31
CRP (mg/dl)
0.20 (0-11.0)
0.20 (0-2.2)
0.20 (0-11.0)
0.68
Total cholesterol (mg/dl)
159 (103-234)
207 (112-345)
176 (103-345)
<0.0001
LDL cholesterol (mg/dl)
81.5 (41-137)
107.5 (54-245)
94.5 (41-245)
0.001
HDL cholesterol (mg/dl)
0.50
Triglycerides (mg/dl)
120.5 (52-320)
174 (66-450)
140 (52-450)
0.001
EGFR (ml/min/1.73 m2)
71.3 (18.0-106.3)
49 (22.6-106.2)
59.6 (18.0-106.3)
0.013
UPCR (g/g)
0.13 (0.01-3.6)
0.17 (0.01-6.0)
0.15 (0.01-6.0)
0.2
values of independent -test and Mann–Whitney test for differences of variables and χ2 test for differences in frequencies among groups. Ox-LDL: oxidized low-density lipoprotein; CV: cardiovascular; T2DM: type 2 diabetes mellitus; BMI: body mass index; SBP: systolic blood pressure; DBP: diastolic blood pressure; HbA1c: glycated hemoglobin A1c; CRP: C-reactive protein; HDL: high-density lipoprotein; eGFR: estimated glomerular filtration rate; UPCR: urinary protein to creatinine ratio.
