Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation

<div>Activation of SIRT1 alleviates CIN. CIN was induced by the intravenous injection of the CM iopromide (1.8 g/kg). The SIRT1 inhibitor EX527 (500 mg/kg) or/and SIRT1-specific activator SRT1720 (500 mg/kg) were injected intravenously before establishment of CIN. The kidney samples were collected 24 h after CM injection. (a1) Representative HE staining of kidney sections and (a2) pathological scores. Serum Cr (b) and BUN (c) levels of rats were measured 24 h after CM injection. (d) CCr was measured 24 h after CM injection. 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Oxidative Medicine and Cellular Longevity

fig4

Figure 4

Figure 4: Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation 