Calorie Restriction Protects against Contrast-Induced Nephropathy via SIRT1/GPX4 Activation

Figure 6

Fer-1 prevented renal injury in CIN. SD rats were pretreated with Fer-1 for 30 min, followed by injection of CM and euthanasia at 24 h. (a1) Fer-1 decreased histologic injury in kidneys from rats exposed to CM ( μm). (a2) Pathological scores were calculated. Serum Cr (b) and BUN (c) levels were measured 24 h after CM injection. (d1) Tissue oxidative stress level in the renal outer medulla, measured using DHE ( μm). (d2) The quantitative mean fluorescence intensity in each treatment group is shown. The renal levels of MDA (e) and GSH/GSSG ratio (f) were measured to determine the oxidative stress. The values are presented as (, vs. control, ^& vs. CM).

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