Research Article
Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury
Figure 7
Effect of lncRNA 39868 silencing. (a) Silencing lncRNA 39868 inhibited the expression of PDGFD mRNA in cardiomyocytes. (b) CaSR-stimulated PMN-derived exosomes increased the expression of lncRNA 39868 and PDGFD, and silencing lncRNA showed the opposite results in cardiomyocytes. (c) The apoptotic rate of cardiomyocytes. (d) The expression of Bcl-2, Bax, and PDGFD in cardiomyocytes. (e) Expression of ROS and TNF-α in cardiomyocytes. (f) MDA and SOD levels in cardiomyocytes. Data are shown as the ; vs. control group, △ vs. H/R group, ○ vs. CIN-PMNs-EXOs group, # vs. H/R + CIN-PMNs-EXOs +siRNA group. Data are representative of three independent experiments.
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