Exosomes Released from CaSR-Stimulated PMNs Reduce Ischaemia/Reperfusion Injury

Figure 8

The exosomes from CaSR-stimulated PMNs significantly increased PDGFD levels in cardiomyocytes after H/R or I/R injury. (a) After myocardial tissue ischaemia and reperfusion, PDGFD protein levels were reduced in cardiac tissues. vs. the sham group, ^Δ vs. the AMI group. (b) The expression of PDGFD in cardiomyocytes after coculture with PMNs. ^# vs. the control group, vs. the H/R group, and ^△ vs. the H/R+PMNs group. (c) PMN function can be inhibited by GW4869. ^# vs. the control group, vs. the H/R group, and ^△ vs. the CIN group. (d) In cardiomyocytes, the expression of PDGFD after coculture with exosomes released from PMNs was detected by western blot. Data are shown as the ; ^# vs. the control group, vs. the H/R group, and ^△ vs. the H/R+CIN PMNs EXOs group.

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