MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation

Figure 7

MED1 deficiency in macrophages on intimal hyperplasia after vascular injury. After ligation, the deficiency of MED1 led to the generation of more ROS and proinflammatory cytokines from macrophages to stimulate the proliferation and migration of smooth muscle cells, which in turn led to aggravated neointimal hyperplasia.