Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer’s Disease

Figure 1

Coumarin-chalcone derivatives. (a) Structure, formula, and molecular weight of tested LM-016, LM-021, and LM-022. (b) Radical-scavenging activity of kaempferol (as a positive control), LM-016, LM-021, and LM-022 (10−160 μM) evaluated by using DPPH (). The EC₅₀ values are shown below. (c) Aβ aggregation-inhibitory effects of curcumin (as a positive control), LM-016, LM-021, and LM-022 (5–20 μM) and ΔK280 tau_RD aggregation-inhibitory effects of Congo red (as a positive control), LM-016, LM-021, and LM-022 (1–10 μM) evaluated by the Thioflavin T assay (). To normalize, the Thioflavin T fluorescence of Aβ₄₂/ΔK280 tau_RD without compound treatment was set as 100%. The EC₅₀ values are shown in the following.

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