Novel Synthetic Coumarin-Chalcone Derivative (E)-3-(3-(4-(Dimethylamino)Phenyl)Acryloyl)-4-Hydroxy-2H-Chromen-2-One Activates CREB-Mediated Neuroprotection in Aβ and Tau Cell Models of Alzheimer’s Disease

Table 1

Summary of PK parameters for LM-021 in ICR male mice.

Sample type	C0 (ng/ml)	(h)	MRT (h)	AUC(0-∞) (ng·h/ml)^a	CL (ml/min/kg)	(l/kg)	Brain/plasma ratio^b
Plasma							0.053
Brain^a	NA		NA		NA	NA

^aThe brain tissue density was assumed to be 1 g/ml. ^bBrain-plasma ratio was calculated by the AUC_(0-∞) ratios. NA: not applicable; C₀: concentration at time zero; : elimination half-life; MRT: mean residence time; AUC_(0-∞): the area under the concentration-time curve from time 0 extrapolated to infinity; CL: body clearance; : an estimate of the volume of distribution at steady state.