Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation <i>In Vitro</i> and Ameliorates Osteoarthritis <i>In Vivo</i>

<div>ECH inhibits TBHP-induced ER stress in chondrocyte cells. (a) The mRNA expression of GRP78, ATF4, and CHOP was measured by real-time PCR. (b, c) The protein expressions of p-PERK, GRP78, p-eIF2<i>α</i>, and CHOP in mouse chondrocytes treated as above were visualized by western blot. (d, e) The representative CHOP was detected by immunofluorescence combined with DAPI staining for nuclei (bar: 20 <i>μ</i>m). 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Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation <i>In Vitro</i> and Ameliorates Osteoarthritis <i>In Vivo</i> 

Figure 3 | Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation In Vitro and Ameliorates Osteoarthritis In Vivo 