Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation <i>In Vitro</i> and Ameliorates Osteoarthritis <i>In Vivo</i>

<div>ECH upregulates the expression of Sirt1 in TBHP-stimulated chondrocytes. (a, b) Protein expression levels of Sirt1 were evaluated by western blot analysis. (c, d) Sirt1 immunofluorescence staining. Markedly increased green bright puncta indicated the upregulated expression of Sirt1 (bar: 20 <i>μ</i>m). (e, f) The protein expression levels of Sirt1 were assayed by western blot analysis. 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Oxidative Medicine and Cellular Longevity

fig5

Figure 5

Figure 5: Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation <i>In Vitro</i> and Ameliorates Osteoarthritis <i>In Vivo</i> 

Figure 5 | Echinacoside Upregulates Sirt1 to Suppress Endoplasmic Reticulum Stress and Inhibit Extracellular Matrix Degradation In Vitro and Ameliorates Osteoarthritis In Vivo 