Gasotransmitters: Potential Therapeutic Molecules of Fibrotic Diseases

Figure 4

The interference mechanisms of H₂S in fibrotic diseases. H₂S can effectively slow down the process of fibrosis through inhibiting the NF-κB, TGF-β, and IL-4/STAT6 signaling pathways, as well as attenuating the production of ROS via downregulation of NOX2/4. Moreover, H₂S can also inhibit the formation of NLRP3 inflammasome and the process of aging to control the occurrence and development of fibrosis.