Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction
Angiotensin II triggered human NP cells senescence in a dose-dependent manner. (a) The SA-β-gal staining of human NP cells induced by Ang II (). (b) Quantitative results of SA-β-gal-positive NP cells in different groups (). (c) Immunofluorescence results for the expression of γH2AX in human NP cells treated by Ang II ().. (d) The expression of γH2AX was quantified as averaged fluorescent voxels/cell (). (e) The protein expression of senescence-related markers, p53, and Klotho in human NP cells induced by Ang II ().,,,.
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