Tissue Renin-Angiotensin System (tRAS) Induce Intervertebral Disc Degeneration by Activating Oxidative Stress and Inflammatory Reaction

Figure 9

Local activated ACE/Ang II accelerated intervertebral disc degeneration in the aging SHR model. (a) SO-FG staining of intervertebral disc in the rat NP tissue at the age of 6 and 12 months, respectively (). (b) Immunofluorescence results for the expression of MMP3 and collagen II in the rat NP tissue at the age of 12 months (). (c, d) TUNEL staining and quantified results for apoptotic NP cells in the rat NP tissue at the age of 12 months, respectively (). (e, f) Immunofluorescence results for the expression of Nrf2 and p65 in the rat NP tissue at the age of 12 months (). , , , .

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