Erythrocyte Fraction in Thrombi Is Increased with Serum Iron by Influencing Fibrin Networks via Oxidative Stress

Figure 2

Correlation of serum iron and erythrocyte fraction in thrombi in vivo. (a) There were significant differences between the HI (), MI (), and LI groups () when compared with the NC group (), but the not in the NS group () (). Serum iron concentration was increased with the administration of iron-dextrin. (b) HE images of rat carotid arteries with the thrombi in each group. Red blood cells are in red and granulating area and fibrin are in pink. There were no thrombi in the carotid arteries of rats in the sham group. (c) Significant differences in erythrocyte fraction in the thrombi between the HI (), MI (), LI (), and NC groups () and no significant differences between the NS () and NC groups (). Erythrocyte fraction in thrombi increased in the presence of serum iron. Results are expressed as , ; ns: ; . Scale at 100x magnification or 100 μm at 200x magnification.

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