TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization

<div>TL1A involves in M1 macrophage polarization and recruitment through the induction of cytokines. The expression of TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 in BMMs and KCs (a1) and these supernatant (a2) was detected by quantitative real-time PCR and ELISA, respectively. (b1) The expression of CCL2 in BMMs and KCs and these supernatant was detected by quantitative real-time PCR and ELISA, respectively. (b2) The expression of CXCL1 in BMMs and KCs and these supernatant was detected by quantitative real-time PCR and ELISA, respectively. (b3) The expression of CCR2 and CXCR2 in BMMs and KCs was detected by quantitative real-time PCR. (b4) The expression of CCR2 and CXCR2 in BMMs and KCs was detected by Western blotting. 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Oxidative Medicine and Cellular Longevity

fig6

Figure 6

Figure 6: TNF-Like Ligand 1 Aberrance Aggravates Nonalcoholic Steatohepatitis via M1 Macrophage Polarization 