Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis

<div>Analysis of peripheral blood from young <i>Pon2<sup>-/-</sup></i> mice compared to WT mice of the same age. Shown are (a) the white blood cell count (WBC), (b) hemoglobin (Hb), (c) red blood cell count (RBC), (d) mean corpuscular volume (MCV), (e) mean corpuscular hemoglobin (MCH), (f) mean corpuscular hemoglobin concentration (MCHC), and (g) red cell distribution width (RDW), in blood of young WT and PON2<sup>-/-</sup> mice. Dot plot diagram. 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n.s. = not significant; <span class="nowrap"><svg height="8.02022pt" id="M28" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg>-</span>test.</div>

Oxidative Medicine and Cellular Longevity

fig3

Figure 3

Figure 3: Deficiency of Antioxidative Paraoxonase 2 (Pon2) Leads to Increased Number of Phenotypic LT-HSCs and Disturbed Erythropoiesis 