Exogenous and Endogenous Serine Deficiency Exacerbates Hepatic Lipid Accumulation
Serine deficiency resulted in increased body weight gain and impaired liver morphology: (a) body weight gain, (b) liver weight, ALT (c) and AST (d) concentrations in serum, and (e) HE staining (×200). Arrows, impaired hepatocytes. CONT: mice were fed on the control diet; NS: mice were fed on the serine-and glycine-deficient diet; NCT: mice were fed on the control diet and supplemented with NCT-503. ALT: alanine aminotransferase; AST: aspartate aminotransferase. Data are presented as .. Mean values were significantly different between CONT and NCT, NS ().
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