Exogenous and Endogenous Serine Deficiency Exacerbates Hepatic Lipid Accumulation

Figure 3

Serine deficiency aggravated oxidative and inflammatory status in liver. GSH: glutathione. Relative mRNA expression of IL-1β (a), TNF-α (b), and IL-6 (c). (d) GSH content in the liver. (e) ROS content (red) in the liver. (f) Relative fluorescence of ROS staining. CONT: mice were fed on the control diet; NS: mice were fed on the serine- and glycine-deficient diet; NCT: mice were fed on the control diet and supplemented with NCT-503. Data are presented as . for the mRNA expression and GSH content and for ROS staining. ^a,bMeans of the bars with different letters were significantly different among groups ().

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