Oxidative Medicine and Cellular Longevity / 2021 / Article / Fig 4

Research Article

Exogenous and Endogenous Serine Deficiency Exacerbates Hepatic Lipid Accumulation

Figure 4

Dietary NCT-503 supplementation decreased serine content in liver. PHGDH: phosphoglycerate dehydrogenase; PAST1: phosphoserine aminotransferase; PSPH: phosphoserine phosphatase. Serine content in serum (a) and liver (b). (c) PHGDH activity. Relative mRNA expression of PAST1 (d) and PSPH (e). CONT: mice were fed on the control diet; NS: mice were fed on the serine-and glycine-deficient diet; NCT: mice were fed on the control diet and supplemented with NCT-503. Data are presented as . . a,b,cMeans of the bars with different letters were significantly different among groups ().

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