Exogenous and Endogenous Serine Deficiency Exacerbates Hepatic Lipid Accumulation

Figure 5

Dietary serine deficiency altered microbiota composition in colonic content. (a) Shannon index. (b) Chao1 index. (c) β-Diversity. (d) PCoA plot of the microbiota based on an unweighted UniFrac metric. (e) Relative abundance of predominant bacteria at the phylum level. (f) Ratio of Firmicutes to Bacteroidetes. (g) Relative abundance of predominant bacteria at the genus level. (h) Relative abundance of Bifidobacterium. CONT: mice were fed on the control diet; NS: mice were fed on the serine- and glycine-deficient diet; NCT: mice were fed on the control diet and supplemented with NCT-503. Data are presented as . for the CONT group and for the NCT and NS group. ^a,bMeans of the bars with different letters were significantly different among groups (). ^A,BMeans of the bars with different letters were tended to differ between NS and CONT and NCT (, which was considered as a tendency).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)