Design-Based Stereology of the Lung in the Hyperoxic Preterm Rabbit Model of Bronchopulmonary Dysplasia

Figure 2

Effect of hyperoxia treatment on lung volume and parenchymal volume. Total lung volume (a) was assessed with volume displacement. Changes in the parenchymal (b) and nonparenchymal (c) lung compartments were further quantified using stereology. Representative microimages of lung samples embedded in glycol methacrylate and stained with toluidine blue are shown in images (d) (normoxia) and (e) (hyperoxia). Lines indicate statistical differences between groups (), assessed with -test or Mann–Whitney rank sum test if normality distribution failed.

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