Design-Based Stereology of the Lung in the Hyperoxic Preterm Rabbit Model of Bronchopulmonary Dysplasia

Figure 4

Histopathology of alveolar and septal structures in normoxia- and hyperoxia-treated rabbit lungs. Representative microscopic images of lung sections embedded in glycol methacrylate and stained with toluidine blue of normoxia- (a, c) and hyperoxia- (b, d) exposed rabbit pups. While the mean alveolar volume is similar between the two exposure groups, an increase in septal thickening and alveolar edema and inflammation (arrowheads) (d) is apparent in the hyperoxia-exposed rabbit lungs.

(a)

(b)

(c)

(d)