Quercetin Impact in Pancreatic Cancer: An Overview on Its Therapeutic Effects

Table 1

A number of pharmacological activities of quercetin reported in recent studies.

Dose	Model	Administration	Activity	Ref.
25 μM	MCF-7 and MDA-MB-231	Direct treatment	Apoptosis induction and anticancer effect	[129]
20 μM	Human umbilical vein endothelial cells (HUVECs)	Direct treatment	Autophagy and promoted cell survival	[130]
5.7 μM (DPPH assay)	Erythrocytes	Direct treatment	ROS and free radical scavenging activity	[131]
100 mg kg^-1	C57BL/6J mice on ethanol-containing Lieber De Carli liquid diets	Gavage	Suppressed autophagic flux, decreased liver injury by ethanol consumption	[132]
100 mg kg^-1	Streptococcus suis infected mice	Subcutaneous	Antimicrobial effect against Streptococcus suis	[133]
100 mg kg^-1	Chronic ethanol feeding C57BL/6J mice	Oral	Decreased fat accumulation in liver (ethanol induced)	[134]
30 mg kg^-1	STZ-induced diabetic rats	Intraperitoneal	Higher insulin levels, improved dyslipidemia, reduced serum blood glucose levels, decreased oxidative stress	[135]
100-200 mg kg^-1	STZ-induced diabetic Wistar rats	Oral	Controlled insulin resistance, reduced blood sugar, pancreatic cells protection	[136]
5-20 mg kg^-1	STZ-induced diabetic rats	Oral	Controlled body weight and blood glucose, performance in the Morris water test	[137]
40 mg kg^-1	STZ-induced diabetic mice in the Morris water maze task	Oral	Enhanced the time spent by mice in the target quadrant in the Morris water maze task	[138]