Structure and Function of Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs) and Their Role in Cardiovascular Diseases

Figure 5

MAM-enriched proteins as potential new therapeutic targets for treatment of CVD-associated pathologies. MAM regulates some major cellular processes, including lipid metabolism, ROS, endoplasmic reticulum pressure, calcium homeostasis, apoptosis and autophagy, and mitochondrial function. The abnormality of these processes often leads to CVD. Notably, the key regulatory proteins of these processes can serve as potential therapeutic targets for CVD.