LINC00467, Driven by Copy Number Amplification and DNA Demethylation, Is Associated with Oxidative Lipid Metabolism and Immune Infiltration in Breast Cancer

Figure 4

Epigenetics and transcriptional regulatory mechanisms of LINC00467. (a) Heat map of the correlation between chromatin openness and LINC00467 expression based on the BRCA ATAC-Seq data and the expression data of the UCSC Xena database. (b) Correlation analysis of chromatin openness and expression level in LINC00467 promoter. (c) Association of chromatin openness of LINC00467 and the prognosis. (d) The significant differences of the methylation in LINC00467 promoter of BRCA. (e) Heat map of correlation between the methylation in LINC00467 promoter and LINC00467 expression. (f) The significant correlation between the methylation in the promoter and the expression of LINC00467. (g) The expression of LINC00467 in 5-aza-deoxycytidine treated cells was detected by qRT-PCR. (h) Active histone modifications of H3K27ac and H3K4me3 and sensitivities of DNA enzyme near the LINC00467 promoter in BRCA cells based on UCSC. .

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